The expanding pharmaceutical sector and international partnerships are facilitating access to innovative therapies. Challenges such as limited healthcare resources are being addressed through policy reforms and investments in diagnostic facilities. The focus on expanding treatment options and clinical research is expected to accelerate market growth, making Pakistan an emerging hub for pancreatic and bile duct cancer therapeutics in the region.
🔢 Listings & Vendors
Addressing this challenge requires deep domain knowledge and expertise, which is constantly evolving. Another limitation is pointed out in the paper that multiple online suppliers might belong to the same vendor. This problem might be addressed by studying the product overlapping patterns over time to merge suppliers, which might reveal more interesting hierarchical clustering patterns. Another important source of information is the trading cash flow, which is recorded in the block chain and might contribute to a comprehensive view of the supply-demand relationship. We did not include such analyses due to the time and scope constraints, and it is a topic that we plan to investigate further. In our study, we found that 23.78% (9896/41,614) listings and traces were identified with the help of 58 opioid jargons (Table 2).
Data
Most recently, Swiss pharma behemoth Novartis unveiled plans to build a new radioligand therapy manufacturing facility in Winter Park, Florida, as part of a $23 billion U.S. investment pledge announced in April 2025. For a platform operating in a space where privacy is paramount, every detail matters. The metadata revealed not only the tools used but hinted at the environment in which the logo was crafted. Mac OS, a favorite among creative professionals, appeared to be the operating system of choice. But what could have been a mere quirk of a designer’s preference quickly escalated into a glaring oversight, setting off alarm bells among cybersecurity experts.
- From our measurement, we concluded that anonymous online marketplaces and forums provided easy-access platforms for global opioid supply.
- These shadow operators have been romanticized in Hollywood films that present them in the archetype of the rugged frontiersman and cowboy who does what is necessary to defeat the nation’s evil, and invariably, dark-skinned foes.
- The agency, based in The Hague, built intelligence based on evidence from Germany, which it said seized the marketplace’s “criminal infrastructure” in December 2021.
- Particularly, as shown in Table 8, the United States and the United Kingdom are always in the top 5 advertised origins among years.
- The platform’s creators, likely seasoned veterans of the darknet ecosystem, should have known better than to leave such glaring vulnerabilities.
- The full close of the financing round is expected in the third quarter of this year, with the company reportedly aiming to raise more than $150 million in total.
- The rising burden of risk factors such as smoking and poor diet contributes to higher cancer incidence rates.
- It is a story that blends technical intrigue with the high stakes of the darknet, offering a glimpse into a world where even the smallest mistake can have monumental consequences.
Drugs and the darknet: perspectives for enforcement, research and policy
Our experiment evaluated MALLET on our annotated anonymous marketplace and forum data set (Table 3) using 3 classification algorithms in the document classification tool (package cc.mallet.classify class in MALLET’s JavaDoc API [Application Programming Interface]). We also applied the MALLET topic modeling toolkit (package cc.mallet.topics MALLET’s class in JavaDoc API) on the same data set to predict the type of topic. The baseline model was applied directly to the labeled data (Table 3) and evaluated using 10-fold cross-validation. We used the metrics of precision and recall to compare the performance of different topic modeling methods. As shown in Table 4, our results indicate that our approach significantly outperforms MALLET and the baseline model in terms of both precision and average recall.
Traitor Logo: How One File Revealed DrugHub’s Shadowy Empire
A single misstep can cascade into a catastrophic failure, as DrugHub’s saga so vividly illustrates. DrugHub’s origins trace back to the remnants of White House Market and its eventual merger with Supermarket. The platform’s creators, likely seasoned veterans of the darknet ecosystem, should have known better than to leave such glaring vulnerabilities. Yet, these oversights suggest a departure from the meticulous operational security (OPSEC) practices that once defined successful darknet marketplaces. Our modification of the semantic comparison model will generate comparable word embeddings for opioid jargon words in legitimate documents (ie, benign corpora embedding) and in underground corpora (ie, underground corpora embedding). Specifically, our modification used a series of opioid keywords collected to generate their benign corpora embeddings and then searched for words whose underground corpora embeddings were close to the opioid keywords’ benign corpora embeddings.
Vietnam Pancreatic And Bile Duct Cancer Market characteristics
Our opioid jargon identification procedure implemented a modified semantic comparison model [19]. This model employed a neural network–based embedding technique to analyze the semantics of words in different corpora. In particular, in the semantic comparison model, the size of the input layer was doubled while not expanding either the hidden or the output layer. Hence, every word has 2 vectors, each describing the word’s relations with other words in one corpus.
It Leasing And Financing Market Emerging Trends and Dynamics Vietnam Indonesia Pakistan Sri Lanka
That same report concluded the health ministry did not provide a thorough, evidence-based business case for the hub model and did not provide proper impact analysis or do proper consultations with all affected people. With its business-friendly environment and Texas Medical Center’s biomanufacturing project, TMC BioPort, the state proved an attractive investment location for other companies in 2025, too. Novartis plans to build two new radioligand therapy manufacturing facilities in Florida and Texas, and in October, the U.K.’s AstraZeneca opened an expanded manufacturing facility in Coppell to double the production of its high blood potassium treatment, Lokelma.
- The market for pancreatic and bile duct cancer drugs in Bangladesh is set to expand, driven by increasing disease prevalence and ongoing healthcare reforms.
- We used the metrics of precision and recall to compare the performance of different topic modeling methods.
- The use of outdated software was not just a cosmetic flaw; it signaled a broader negligence in keeping up with technological advancements.
- Ourexperienced moderation team reviews all cases within 3-7 days, ensuring fairresolution based on evidence and platform policies.
- Latin America offers emerging growth potential through infrastructure expansion and rising industrial activity, while the Middle East & Africa benefits from growing investments in energy, construction, and smart infrastructure projects.
- Your support helps facilitate this compensation as well as increase the caliber of this work.
🔐 Why Choose DrugHub?
Drug Hub operates a private Jabber server for push notifications and optional vendor communication.
Hôtel-Dieu Grace Healthcare (Windsor)
International collaborations and investments in healthcare technology are fostering innovation and market development. The focus remains on enhancing treatment accessibility and integrating advanced therapies, positioning Bangladesh as an emerging market for pancreatic and bile duct cancer management in South Asia. The opioid buyer (client) will also access the anonymous online market and create an account in each anonymous marketplace before they can find the listings of opioids (step 4). After perusing the items available on the anonymous online market (step 5), the buyer will add opioids to their shopping cart (step 6). When the buyer wants to check out and make a purchase using cryptocurrency (eg, Bitcoin), if the trader accepts payment through an anonymous online marketplace as an escrow, the buyer will place the listed amount of cryptocurrency in escrow (step 7). Otherwise, the buyer will pay the trader directly using cryptocurrency or any other payment method accepted by the trader (step 9) [7].
Services and Housing in Province (Dufferin County)
To better understand the potential bundling relationship of opioid suppliers across different marketplaces, we calculated the Jaccard similarity coefficient between the suppliers in different marketplaces (Figure 6). We found that 182 opioid supplier IDs appeared in both the marketplaces Evolution and Agora from January 2014 to July 2015. In particular, we observed that 84 opioid supplier IDs synchronized similar product listings in both marketplaces at the same time. This might be because the suppliers tend to promote their products across various marketplaces and to increase sales.
Emerging markets are showing promising potential due to improving healthcare infrastructure and heightened awareness. This analysis provides a comprehensive overview of the current market landscape, key regional trends, and the technological innovations shaping the future of pancreatic and bile duct cancer treatments across diverse geographic regions. This joint report prepared by the EMCDDA and Europol considers the latest findings from international research, fresh empirical data, and operational information and intelligence in order to illuminate how darknet markets function and how they relate to criminal behaviour. It is comprehensive but accessible and policy-oriented, intended to facilitate discussions at EU-level on how to respond to darknet drug markets, whilst identifying key priority areas that require attention and where activities are likely to have most impact. As observed in our data set, the opioid suppliers in the marketplaces Evolution, Pandora, and Silk Road accepted escrow as a method of payment. In fact, the shutdown of the marketplace Evolution was discovered to be an exit scam, with the site’s operators shutting down abruptly to steal the approximately US $12 million in bitcoins that it was holding as an escrow [39].
🛡️ Advanced Security & Privacy
It also recently announced plans to build a second multibillion-dollar facility in Wilson. Speculation abounds that DrugHub’s servers may have already been compromised by law enforcement. If true, this would not only spell disaster for the platform’s users but also serve as a stark reminder of the stakes involved in operating within this clandestine realm. In this way, we collected 7100 promotion posts and 6408 review posts from forum posts in total. Finally, in the model refining stage, the model is trained for other 2 iterations using the same objective function.
Novartis broke ground on a 700,000-square-foot flagship manufacturing hub in December. Slated to open in by 2028, the project includes a new facility in Morrisville and a new site in Durham, as well as expansion of an existing Novartis facility in Durham. From a seemingly innocuous logo to systemic vulnerabilities, DrugHub’s downfall is a testament to the importance of vigilance in the digital age. It is a story that blends technical intrigue with the high stakes of the darknet, offering a glimpse into a world where even the smallest mistake can have monumental consequences. For now, the fate of DrugHub hangs in the balance, a stark reminder that even in the shadows, the light of scrutiny can find a way in.
Official
- 🚨 DrugHub is the leading darknet marketplace for verifiedvendors, over 100,000+ listings, over 500,000 active users, and more than 4,000 trusted vendors.
- We output the top 100 proper nouns in the underground corpora in our implementation, whose embeddings showed the closest cosine distance to the known opioid keywords.
- It is a priority for CBC to create products that are accessible to all in Canada including people with visual, hearing, motor and cognitive challenges.
- The baseline model was applied directly to the labeled data (Table 3) and evaluated using 10-fold cross-validation.
- Once the item is received, the buyer finalizes the purchase by notifying the anonymous online marketplace to release the funds held in escrow (step 11) [8,9].
This finding is roughly in line with the observation of 57 opioid vendors’ origin in a marketplace named Cryptomarket during the period of October 2015 through April 2016, which was reported by Duxbury et al [6]. In addition, we did not observe big changes in the top opioid commodity origins from 2014 to 2020. Particularly, as shown in Table 8, the United States and the United Kingdom are always in the top 5 advertised origins among years. Co-occurrence of the same opioid suppliers across different anonymous marketplaces. We compared our method with the state-of-the-art topic modeling method Machine Learning for Language Toolkit (MALLET) [30] and our model without transfer learning stage (baseline).
It’s part of a bigger $1.2 billion investment in advanced manufacturing facilities, AI and advanced digital technologies that will also include new capabilities. With Philadelphia a long-established pharma hotspot and Pittsburgh an emerging one, Pennsylvania’s life sciences sector employs 100,000 workers across nearly 3,100 companies that have secured more than 10,700 new life sciences patents over the past five years. Everything’s bigger in Texas, the saying goes, and that’s true of Eli Lilly’s plans to build a new $6.5 billion manufacturing facility in Houston, marking one of the state’s biggest life sciences investments.
Dr Dayan Goodenowe launches flagship plasmalogen products in Japan
Among them, suboxone and subutex medicines are most frequently mentioned by 2917 times in listings and traces in 10 platforms, followed by roxy series (ie, roxy, roxi, roxies, and roxys) with 2022 times and Lean with 1256 times. Both K9 and M30 were mostly found in Darkbay, within 384 listings in the year 2020, whereas Lean appeared 141 times in Empire listings. As a pioneer in organoid technology, HUB offers transformative solutions to the pharmaceutical industry for more effective, faster, and ethical drug development. HUB develops disruptive PDOs that accurately replicate human drug responses compared to animal models and cell lines, greatly increasing the value and impact of drug development programs. Our team of seasoned analysts and researchers combines advanced methodologies, reliable data sources, and cutting-edge tools to produce detailed market reports, customized consulting solutions, and strategic recommendations.
We are a pan-Canadian collective of harm reductionists, drug policy activists, and people who use(d) drugs. Drug Hub features a unique mirror distribution system where each user receives personal mirror links. Unlike traditional marketplaces with shared backup mirrors, our system provides truly unique onion addresses for enhanced security and reliability. Last month, a social services agency in Toronto launched a legal challenge against the law limiting supervise consumption sites, arguing it infringes on the Charter rights to life, liberty and security of person.
- We first conducted a whole-site crawl of anonymous online marketplaces and forums to solicit data.
- Overdose deaths involving heroin began increasing in 2000 with a dramatic change in pace, and as of 2014, 61% of drug overdoses involved some type of opioid, inclusive of heroin [1].
- This onion is protected by custom sophisticated CAPTCHA systems and POWenabled to give you the best experience using DrugHub market.
- As observed in our data set, the opioid suppliers in the marketplaces Evolution, Pandora, and Silk Road accepted escrow as a method of payment.
The expanding pharmaceutical sector and government initiatives to improve cancer care infrastructure are crucial factors. Additionally, the growing prevalence of these cancers among the aging population is expected to boost demand for advanced therapeutics. Market players are increasingly focusing on local collaborations and clinical research to enhance treatment options tailored to regional patient needs.
Indonesia’s pancreatic and bile duct cancer drug market is anticipated to expand rapidly, driven by increasing disease awareness and a burgeoning healthcare sector. Government initiatives aimed at improving cancer screening and treatment infrastructure are pivotal. The rising prevalence of risk factors such as smoking and obesity contributes to higher cancer incidence. Market growth is further supported by international collaborations and investments in healthcare technology.
Become part of the #1 darknet marketplace trusted by over 500,000 users and 100k+ listings. Frost & Sullivan Best Practices Awards recognize companies in various regional and global markets for demonstrating outstanding achievement and superior performance in leadership, technological innovation, customer service, and strategic product development. Industry analysts compare market participants and measure performance through in-depth interviews, analyses, and extensive secondary research to identify best practices in the industry.
All communications and sensitive data are protected using Pretty GoodPrivacy (PGP) encryption with 4096-bit keys, ensuring complete privacy fromthird-party interception. This onion is protected by custom sophisticated CAPTCHA systems and POWenabled to give you the best experience using DrugHub market. This said… at this point in time I would not be surprised if DrugHub has been had it’s servers imaged by Law Enforcement and investigations at this point are probably underway. The Ministry of Health works to help people stay healthy, delivering high-quality care when they need it and protecting the health system for future generations.
We partner with organizations of all sizes—from startups to Fortune 500 companies—to help them optimize strategies, strengthen competitiveness, and drive sustainable growth. Our commitment to quality research and client success has established us as a trusted name in global market intelligence. The Pancreatic And Bile Duct Cancer Drug Market refers to the global industry involved in the development, production, and deployment of Pancreatic And Bile Duct Cancer Drug solutions across various end-use drughub.su sectors. He hung around with a rough crowd of Special Forces operatives in Fayetteville who drank heavily, took copious amounts of drugs and told graphic war stories in each others’ company while boasting about the numbers of people they had killed. The layout, coded from scratch, is different from White House Market but remains intuitive for experienced darknet users. Experience the future of secure, anonymous trading with Drughub Market’scutting-edge platform and trusted community.
We then identified 311 opioid keywords and jargons to recognize 28,106 listings and 13,508 forum traces related to underground opioid trading activities. Finally, we used natural language processing techniques to extract opioid trading information to characterize underground opioid commodities, suppliers, and transactions. Our research collected product listings and forum posts from 10 anonymous online market places and 6 forums. Our study determined the underground marketplace and forum list based on darknet site search engines and previous research works [20]. More specifically, we used darknet site search engines (such as Recon, Darknet live, Dark Eye, dark.fail, and DNStats [21,22]) to search underground marketplaces and forums and then manually validated their activeness. Note that some high-profile underground marketplaces and forums are frequently deactivated or have been shut down by law enforcement authorities [23].
- New vendors without an existing darknet marketplace history can join Drughub Market by paying a $1000 securitydeposit.
- HUB Organoid Technology represents a paradigm shift for drug discovery and development, preclinical patient stratification, predictive diagnostics, personalized medicine, clinical trials, regenerative medicine, and companion diagnostics.
- The award recognizes the quality of the solution and the customer value enhancements it enables.
- This is because the same user could have different IDs, and the same ID in different marketplaces can point to different users.
- Always use Tor Browser with security level set to “Safest.” Encrypt all sensitive communications with PGP.
- With its business-friendly environment and Texas Medical Center’s biomanufacturing project, TMC BioPort, the state proved an attractive investment location for other companies in 2025, too.
The focus on improving access to innovative therapies and expanding clinical research activities positions Indonesia as a promising emerging market for pancreatic and bile duct cancer treatments. Sri Lanka’s pancreatic and bile duct cancer drug market is expected to grow steadily, supported by increased healthcare spending and improved diagnostic capabilities. Rising awareness about cancer symptoms and early detection programs are crucial factors.
Secure escrow system holds funds for 7-21 days depending on productcategory, with automatic release upon delivery confirmation or disputeresolution through our moderation team. Drughub Market employs state-of-the-art security measures to protect yourprivacy and transactions. Paste the mirror URL in Tor browser, complete CAPTCHA verification, andcreate your secure account. Contributors with living/lived expertise of drug use and active students receive a $100 stipend per accepted submission, sent via e-transfer. Learn how we’re helping create safer communities and supporting people struggling with addiction and mental health issues by approving 18 new HART Hubs.
A total of 248,359 listings from 10 anonymous online marketplaces and 1,138,961 traces (ie, threads of posts) from 6 underground forums were collected. Recent years have witnessed the trend of studying opioid use disorders using anonymous marketplaces and forums data [5,8,10] and public social media data (eg, Twitter and Instagram) [11-14]. Gilbert et al [15] described changes in the conceptualizations, techniques, and structures of opioid supply chains and illustrated the diversity of transactions beyond the traditionally linear conceptualizations of cartel-based distribution models. Quintana et al [16] and Fernando et al [17] presented the results of the international drug testing service for opioid commodities from the anonymous marketplaces and showed that most opioid substances contained the advertised ingredient and most samples were of high purity. Dasgupta et al [18] collected opioid listings on Silk Road to analyze the prices of diverted prescription opioids. Duxbury et al [6] evaluated the role of trust in online drug markets by applying exponential random graph modelling to underground marketplace transactions.
Revolutionizes pre-clinical and clinical drug development through its cutting-edge organoid technology, enhancing its accuracy and efficiency. Market Research Intellect (MRI) is a trusted provider of comprehensive market intelligence, delivering actionable insights that enable businesses to make informed, strategic decisions. With a focus on accuracy, depth, and relevance, we specialize in analyzing global markets across diverse industries including healthcare, technology, chemicals, consumer goods, energy, and more.
We manually investigated the results by randomly sampling 10% of data records during each iteration and adding false positive samples into the unlabeled set. The review detection model yielded a mean precision of 81.5% and an average recall of 80.1%, whereas for the promotion detection model, it yielded a mean precision of 88.1% and an average recall of 85.1% (Table 4). At Market Research Intellect, our mission is to bridge the gap between data and decision-making.
In DrugHub’s case, the risks were amplified by its server’s geographical location and its choice of hosting providers. We observed the same listings posted in different marketplaces and illustrate the dependency of the same opioid listings among different marketplaces. Note that we determined if 2 listings are identical by matching the same elements (ie, listing’s title and description information and the vendor’s name) in 2 listings. We observed that the marketplaces of Agora and Evolution shared 530 opioid listings from 290 unique supplier IDs. The opioid commodity with most listings across different marketplaces was #4 White Vietnamese Heroin, which can be found in the marketplaces Agora, Evolution, Hydra, and Pandora. HUB Organoids (HUB) is the global leader in the field of adult stem cell-derived organoids.